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In
nine out of ten cases, increasing hair loss
is genetically determined. Partially responsible
for the baldness is the so-called Dihydrotestosterone,
in short DHT. This is formed with the help
of an enzyme (the 5-alpha-reductase) from
the male hormone testosterone.
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The effect of DHT to the hair roots
DHT influences the shortening of the growth
phase of the hair. Furthermore, the hair
root can observed to mortify and there can
be an increase in the number of so-called
downy hairs.
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How does PROPECIA® work?
The discovery of the 5-alpha-reductase enzyme
reveals new treatment possibilities. If
one succeeds in retaining the enzyme and
suppress it, it is possible for a man to
treat his genetically determined loss of
hair by use of medication.
To be clear: PROPECIA does not take action
in the hormonal regulation! The male hormone
testosterone is not influenced by PROPECIA!
PROPECIA merely stops the effect of the
5-alpha-reductase enzyme and by doing so,
it lowers the concentration of DHT in the
scalp.
In this way, PROPECIA helps to discontinue
the progressive mortification of the existing
hair roots. Hair roots that have already
mortified are stimulated to produce sturdy
hairs again.
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Possible side-effects
As the Dutch saying goes: "Wash me,
but don't make me wet!". We all know
that this is an unattainable desire, and
this also goes for many forms of medication.
All medication can also have side-effects,
beside the positive, desired effect.
The development of e100
ffective substances is now always goal-oriented,
so that side-effects can be reduced. In
the clinical research, only 3.8% of all
males complained about sexual side-effects
which are connected to the intake of PROPECIA
(see also the report of clinical research).
These side-effects certainly took place
during the treatment period and were only
temporary or disappeared after stopping
the intake of PROPECIA.
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The use of PROPECIA
In general, a daily tablet intake is required
for a period of three to six months, before
the effects of it become visible.
In order to maintain this effect optimally,
PROPECIA needs to be used durably.
Because of this, a regular check-up by your
physician is required. There are several
persistent assumptions, which are untrue
in all cases:
· Hair that has been cut short does
not grow faster than long hair
· thin, fine hair does not become
thicker by cutting it regularly
· hair roots cannot be stimulated
by the use of vitamins
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Report of clinical studies
Three
clinical studies found place with 1879 males
in the ages of 18 to 41 years with finasteride
1 mg (PROPECIA®). The males in this
studies with mild to moderate, but not complete,
hair loss.
Two of these studies researched hair loss
of the vertex, and the third study researched
hair loss at the frontal and the middle
part of the scalp.
In the studies of hair loss of the crown,
86% of men treated with finasteride suffered
no further hair loss, or even experienced
an increase of the number of hairs. In only
14% of the patients, further hair loss occurred,
against 58% of the males who received a
placebo.
In 48% of the males who received finasteride
for a period of 12 months, the hair increased.
The males who received a placebo only had
an increase in 7%. The third study was done
with 326 men (aged 20-41) with hair loss
at the front and middle of the scalp. In
37% of these men, the treatment with finasteride
resulted in an increase in hair growth,
against 7% at placebo-basis. Finasteride
was excellently endured in the clinical
research.
The general endurance profile of finasteride
was comparable to that of the placebo. The
number of drop-outs as a result of side-effects
was 1,7% for finasteride, and 2,1% for the
placebo.
Most frequently reported side-effects were:
less desire for sex: 1.8% on finasteride
and 1.3% on placebo; difficulty in achieving
an erection: 1.3 % on finasteride and 0.7
% on placebo; decrease in the amount of
semen: 0.8 % on finasteride and 0.4 % on
placebo. A large majority of the men who
used finasteride (96%) did not report any
side-effects of sexual nature. These side-effects
went away in men who stopped taking PROPECIA.
Moreover, the side-effects disappeared in
many cases in which the patients preferred
to continue with the therapy. The therapy
with finasteride consisted of a daily intake
of a pill of 1 mg. Finasteride has not yet
been registered for the indication of baldness
in the Netherlands. In the Netherlands,
finasteride is only registered in a dose
of 5 mg for the treatment of benign prostate
enlargement. Data from several researches
have been offered to the Medicines Evaluation
Board (Dutch: College ter Beoordeling van
Geneesmiddelen). After registration, Propecia
will only be available at doctor's prescription.
To date, Propecia has been registered amongst
others in the United States, Mexico, New
Zealand, Sweden, Finland, Denmark, Portugal
and Italy.
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